Hypertriglyceridemia and atherosclerosis

Meeting Summary Relationship of Hypertriglyceridemia to Atherosclerosis

O June8-10,1981, the Lipid Metabolism-Atherogenesis Branch of the National Heart, Lung, and Blood Institute sponsored a workshop entitled, "The Relationship of Hypertriglyceridemia to Atherosclerosis," in Bethesda, Maryland. The purpose of the workshop was to bring together a large number of investigators with primary interests in epidemiology, genetics, nutrition, pathology, and basic and clin...

Associations with Hypertriglyceridemia, Lipoprotein Modifying Enzymes and Atherosclerosis

CD36 Inhibitors Reduce Postprandial Hypertriglyceridemia and Protect against Diabetic Dyslipidemia and Atherosclerosis

CD36 is recognized as a lipid and fatty acid receptor and plays an important role in the metabolic syndrome and associated cardiac events. The pleiotropic activity and the multiple molecular associations of this scavenger receptor with membrane associated molecules in different cells and tissues have however questioned its potential as a therapeutic target. The present study shows that it is po...

Hypertriglyceridemia

Hypertriglyceridemia (HTG) is commonly encountered in lipid and cardiology clinics. Severe HTG warrants treatment because of the associated increased risk of acute pancreatitis. However, the need to treat, and the correct treatment approach for patients with mild to moderate HTG are issues for ongoing evaluation. In the past, it was felt that triglyceride does not directly contribute to develop...

The Role of Hypertriglyceridemia in the Development of Atherosclerosis and Endothelial Dysfunction

A hereditary postprandial hypertriglyceridemic rabbit (PHT rabbit) is a new dyslipidemic model showing remarkably high plasma triglycerides with only limited elevation of plasma total cholesterol. In PHT rabbits, plasma triglyceride was markedly elevated postprandially compared with healthy Japanese white (JW) rabbits. In physiological experiments, the ring preparation of the thoracic aorta was...